METHOD FOR PRODUCING CRYSTALS FROM ACTIVE INGREDIENTS IN MEDICAMENTS, AND THE USE THEREOF IN PHARMACEUTICAL FORMULATIONS

摘要

The invention relates to a method for producing crystals from active ingredients in medicaments, the average particle size thereof lying within a given range and the maximum particle size thereof not exceeding a given value. During crystallisation, an oversaturated solution is subjected to wet milling by means of a wet milling device; as a result, a primary grain suspension is obtained. The invention also relates to crystals obtained according to said method and pharmaceutical formulations containing said crystals.