| 发明名称 |
Anaplastic Lymphoma Kinase (ALK) As An Oncogene Capable Of Transforming Normal Human Cells |
| 摘要 |
The present invention provides compositions and methods for transforming primary mammalian cells using an oncogenic form of ALK wherein the transformed cells display features of that of a corresponding tumor cell isolated from a cancer subject. The invention also provides a method for immortalizing normal CD4+ T lymphocytes with a lymphoma-characteristic form of ALK such as NPM-ALK. |
| 申请公布号 |
US2016194616(A1) |
申请公布日期 |
2016.07.07 |
| 申请号 |
US201514979055 |
申请日期 |
2015.12.22 |
| 申请人 |
The Trustees of the University of Pennsylvania |
发明人 |
Wasik Mariusz;Riley James L.;Zhang Qian;Wei Fang |
| 分类号 |
C12N9/12;C12N15/85 |
主分类号 |
C12N9/12 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. An isolated transformed mammalian cell, wherein the transformed cell is genetically modified to express an oncogenic anaplastic lymphoma kinase (ALK), and wherein the transformed cell exhibits one or more features of that of a corresponding tumor cell isolated from a cancer subject. |
| 地址 |
Philadelphia PA US |
