Adjustable intraocular lens

摘要

Methods and devices for altering the power of a lens, such as an intraocular lens, are disclosed. In one method, the lens comprises a single polymer matrix containing crosslinkable pendant groups, wherein the polymer matrix increases in volume when crosslinked. The lens does not contain free monomer. Upon exposure to ultraviolet radiation, crosslinking causes the exposed portion of the lens to increase in volume, causing an increase in the refractive index. In another method, the lens comprises a polymer matrix containing photobleachable chromophores. Upon exposure to ultraviolet radiation, photobleaching causes a decrease in refractive index in the exposed portion without any change in lens thickness. These methods avoid the need to wait for diffusion to occur to change the lens shape and avoid the need for a second exposure to radiation to lock in the changes to the lens.

主权项

1. A lens comprising a polymer matrix including photobleachable chromophores; and
a UV radiation absorbing layer on at least one surface of the polymer matrix; wherein the chromophores comprise a malonoitrile moiety, or are of the Formula (I), (II), (III), (IV):where R1-R10 are independently selected from hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, —COOH, and —NO2,where R11-R20 are independently selected from hydrogen, alkyl, substituted alkyl, aryl, substituted aryl, —COOH, —NO2; halogen, amino, and substituted amino.