PROTEASE RESISTANT PEPTIDES

摘要

The present invention provides protease-resistant peptides, methods of making such peptides, as well as compositions comprising protease-resistant peptides and method of treatment utilizing such peptides. Incorporation of alpha-methyl-functionalized amino acids directly into the main chain during standard peptide synthesis via the methodologies described herein has been determined to produce protease-resistant peptides.

主权项

1. A synthetic peptide comprising at least one substitution of an alpha-methyl functionalized amino acid for a native amino acid residue, wherein the synthetic peptide maintains substantially the same receptor potency and selectivity as a corresponding synthetic peptide that does not comprise the substitutions.