Iron Chelators and Use Thereof for Reducing Transplant Failure During Rejection Episodes

摘要

Formulations and methods are provided for improving the function, i.e. clinical outcome, of solid organ transplants. Lung transplantation is of particular interest. In the methods of the invention, a nanoparticle formulation comprising an effective dose of an iron chelator active agent in nanoparticle form, including without limitation, deferoxamine (DFO), deferasirox (DFX), and deferiprone (DFP), etc. is topically applied to the surface of tissues during episodes of graft rejection.

主权项

1. A method of improving clinical outcome in an individual following lung transplantation, the method comprising:
directly contacting a bronchial passage of the individual, in a rejection episode following transplantation, with an effective dose of a nanoparticle formulation comprising an effective dose of an iron chelating agent; wherein ischemia and hypoxia at the contacted surface is reduced and clinical outcome is improved.