INTEGRIN TARGETING AGENTS AND IN-VIVO AND IN-VITRO IMAGING METHODS USING THE SAME

摘要

The invention provides a family of agents that target integrins, which can be used as imaging agents and/or therapeutic agents. The agents comprise (a) an integrin targeting moiety (ITM) comprising an alkyl substituted tetrahydro-1,8-naphthyridine moiety, wherein the alkyl is substituted with an aryl or heteroaryl moiety; and (b) a reporter chemically linked, optionally through a linker (L) moiety, to the integrin targeting moiety. The agents can be used to image angiogenesis, inflammation or other physiological processes in a subject.