摘要 |
The present disclosure provides antibodies that specifically bind to human glucocorticoid-induced TNFR family related receptor (GITR) and compositions comprising such antibodies. In a specific aspect, the antibodies specifically bind to human GITR and modulate GITR activity, e.g., enhance, activate or induce GITR activity, utilizing such antibodies. The present disclosure also provides methods for treating disorders, such as cancer and infectious diseases, by administering an antibody that specifically binds to human GITR and modulates GITR activity e.g., enhances, activates or induces GITR activity. |
申请人 |
AGENUS INC.;MEMORIAL SLOAN-KETTERING CANCER CENTER;LUDWIG INSTITUTE FOR CANCER RESEARCH LTD. |
发明人 |
LEGER, OLIVIER;SIEBERT, VOLKER;VAN DIJK, MARC;SCHAER, DAVID;TSUJI, TAKEMASA;RITTER, GERD;GONZALEZ, ANA M.;WILSON, NICOLAS S.;ZAPPASODI, ROBERTA;MERGHOUB, TAHA;WOLCHOK, JEDD DAVID;UNDERWOOD, DENNIS J. |