ENZYMATIC PROCESS FOR THE REGIOSELECTIVE MANUFACTURING OF N-FMOC-DOXORUBICIN-14-O-DICARBOXYLIC ACID MONO ESTERS

摘要

The present invention describes a process for the selective synthesis of N-Fmoc-doxorubicin-14-O-dicarboxylic acid mono ester derivatives starting from N-Fmoc-doxorubicin using lipase enzymes and bis-acyl donor compounds such as dicarboxylic acids or anhydrides.