Antibodies to paliperidone and use thereof

摘要

Disclosed is an antibody which binds to paliperidone, which can be used to detect paliperidone in a sample such as in a competitive immunoassay method. The antibody can be used in a lateral flow assay device for point-of-care detection of paliperidone, including multiplex detection of aripiprazole, quetiapine, olanzapine, and risperidone/paliperidone in a single lateral flow assay device.

主权项

1. An isolated antibody or a binding fragment thereof, which specifically binds to paliperidone and which said isolated antibody or binding fragment thereof is selected from the group of amino acid sequences consisting of:
a) the isolated antibody or the binding fragment thereof comprising a heavy chain variable region, and a light chain variable region wherein said light chain variable region comprising an amino acid sequence of SEQ ID NO:3 or SEQ ID NO:7; b) the isolated antibody or the binding fragment thereof comprising a heavy chain variable region comprising an amino acid sequence of SEQ ID NO:4 or SEQ ID NO:8, and a light chain variable region; c) the isolated antibody or the binding fragment thereof comprising a light chain variable region having an amino acid sequence of SEQ ID NO:3 and a heavy chain variable region having an amino acid sequence of SEQ ID NO:4; or d) the isolated antibody or the binding fragment thereof comprising a light chain variable region having an amino acid sequence of SEQ ID NO:7 and a heavy chain variable region having an amino acid sequence of SEQ ID NO:8.