Perlecan as a biomarker for renal dysfunction

摘要

The application discloses PERLECAN as a new biomarker for renal dysfunction; methods for predicting, diagnosing, prognosticating and/or monitoring said dysfunction based on measuring said biomarker; and kits and devices for measuring said biomarker and/or performing said methods.

主权项

1. A method for treating dyspnea in a subject presenting with rapid onset of the dyspnea, wherein the subject has not had a kidney transplant, and wherein the method comprises:
a) identifying the subject presenting with rapid onset of said dyspnea as having dyspnea associated with or caused by renal dysfunction and as being in need of treatment of renal dysfunction by having an assay conducted, wherein the assay comprises:
(i) contacting an antibody or an aptamer capable of specifically detecting the Endorepellin domain of PERLECAN with a blood sample from the subject;(ii) measuring a quantity of the Endorepellin domain of PERLECAN in the blood sample by determining the binding of the antibody or aptamer to the Endorepellin domain of PERLECAN;(iii) converting the measured quantity of the Endorepellin domain of PERLECAN in the blood sample to a glomerular filtration rate (GFR) value; and(iv) comparing the GFR value determined in (iii) with a reference value GFR value, said reference value representing one or more of a known diagnosis, prediction, or prognosis of renal dysfunction or normal renal function, and finding a reduced GFR value determined in (iii) from said reference value so as to identify the subject as being in need of the treatment for renal dysfunction; and b) treating the subject having the deviation for renal dysfunction, thereby treating dyspnea, with a treatment or therapy selected from the group consisting of low-potassium diet, low phosphorous diet, low potassium and low phosphorus diet, phosphorous-lowering medications, red-blood-cell-production-stimulating agents, iron supplements, blood pressure medications, vitamin supplements, haemodialysis, ultrafiltration, peritoneal dialysis and kidney transplantation.