Compounds and methods for enhanced cellular uptake

摘要

Described herein are conjugated modified oligonucleotides that are complementary to a target RNA. The conjugate facilitates cellular uptake of the modified oligonucleotide, resulting improved potency.

主权项

1. A compound comprising the structure: wherein each N of Nm is, independently, a modified or unmodified nucleoside and m is from 1 to 5; X1 and X2 are each, independently, a phosphodiester linkage or a phosphorothioate linkage; and MO is a modified oligonucleotide; and wherein when m is greater than 1, each modified or unmodified nucleoside of Nm is connected to adjacent modified or unmodified nucleosides of Nm by a phosphodiester internucleoside linkage or a phosphorothioate internucleoside linkage.