| 发明名称 |
QUINOLINYL AND BENZOTHIAZOLYL PPAR-GAMMA MODULATORS |
| 摘要 |
Compounds having the formula (I) wherein Ar1 is substituted or unsubstituted 2- benzothiazolyl or substituted or unsubstituted quinolinyl; X is -O-, -C(O)-, - CH(R10)-, -N(R11)-, or -S(O)k-; Y is -N(R12)-S(O)2-; R1 is hydrogen or a specified substituent; R2 is substituted or unsubstituted aryl; and R3 is halogen or (C1-C8)alkoxy are useful in the treatment or prevention of a condition or disorder mediated by PPAR.gamma.. In particular, the compounds of the invention modulate the function of PPAR.gamma.. The subject methods are particularly useful in the treatment and/or prevention of diabetes, obesity, hypercholesterolemia, rheumatoid arthritis and atherosclerosis. |
| 申请公布号 |
CA2412723(A1) |
申请公布日期 |
2002.01.03 |
| 申请号 |
CA20012412723 |
申请日期 |
2001.06.27 |
| 申请人 |
TULARIK INC.;JAPAN TABACCO, INC. |
发明人 |
HAGIWARA, ATSUSHI;FURUKAWA, NOBORU;SHINKAI, HISASHI;RUBENSTEIN, STEVEN M.;HOUZE, JONATHAN B.;MCGEE, LAWRENCE R. |
| 分类号 |
A61K31/428;A61K31/4439;A61K31/47;A61K31/4725;A61K31/506;A61P3/00;A61P3/04;A61P3/06;A61P3/10;A61P9/10;A61P19/02;A61P29/00;A61P43/00;C07D215/12;C07D215/20;C07D215/36;C07D215/48;C07D277/64;C07D277/68;C07D277/82;C07D417/04;C07D417/12;C07D417/14;(IPC1-7):C07D277/82 |
主分类号 |
A61K31/428 |
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