COMPOSITIONS AND METHODS FOR TREATING AND DIAGNOSING IRRITABLE BOWEL SYNDROME

摘要

The present invention relates generally to therapy and diagnosis of disor ders associated with chronic visceral hypersensitivity (CVH), and in particu lar irritable bowel syndrome (IBS). In particular this invention relates to the polypeptides as well as to the polynucleotides encoding these polypeptid es, wherein said polypeptides are shown to be associated with CVH. These pol ypeptides and polynucleotides are useful in the diagnosis, treatment and/or prevention of disorders associated with CVH, in particular in the diagnosis, treatment and/or prevention of disorders associated with IBS.