| 摘要 |
The present invention provides a process for producing highly pure fluoro-compounds by making use of less costly and readily handleable N-(2-chloro-1,1,2-trifluoroethyl)diethylamine. The process produces little or no chlorinated by-products. Specifically the present invention provides a process for producing a fluoro-compound, comprising fluorinating an alcohol derivative represented by the following general formula (1): <?in-line-formulae description="In-line Formulae" end="lead"?>R1R2R3COH (1)<?in-line-formulae description="In-line Formulae" end="tail"?> (wherein R1 represents a hydrogen atom, a substituted or unsubstituted alkyl group, aryl group, alkylcarbonyl group, alkoxycarbonyl group, arylcarbonyl group or aryloxycarbonyl group; and R2 and R3are each independently a substituted or unsubstituted alkyl group, aryl group, alkylcarbonyl group, alkoxycarbonyl group, arylcarbonyl group or aryloxycarbonyl group, wherein at least two of R1, R2 and R3 may together form part of a ring structure, either with or without a heteroatom) with N,N-diethyl-2-chloro-1,1,2-trifluoroethylamine to form a fluoro-compound represented by the following general formula (2): <?in-line-formulae description="In-line Formulae" end="lead"?>R1R2R3CF (2)<?in-line-formulae description="In-line Formulae" end="tail"?> (wherein R1, R2 and R3 are as defined above), the process being characterized in that an alcohol derivative represented by the following general formula (3): <?in-line-formulae description="In-line Formulae" end="lead"?>R4OH (3)<?in-line-formulae description="In-line Formulae" end="tail"?> (wherein R4 represents a substituted or unsubstituted alkyl group or aryl group) is added to the reaction system.
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