NOVEL NUCLEIC ACID-BASED MOLECULAR PROBES

摘要

The subject invention provides a novel nucleic acid-based molecular probe design employing intramolecular signal transduction. In an embodiment specifically exemplified herein, the probe comprises four elements: an aptamer; a short, partially complementary DNA sequence; a PEG linker conjugating the aptamer with the short DNA strand; and a luminescent molecule attached to a terminus of the aptamer and a terminus of the DNA sequence.