发明名称 |
ARYL SUBSTITUTED CARBOXAMIDE DERIVATIVES AS CALCIUM OR SODIUM CHANNEL BLOCKERS |
摘要 |
The present invention relates to aryl substituted carboxamide derivatives of formula (I) or a pharmaceutically acceptable salt thereof, which have blocking activities of T-type calcium channels or voltage gated sodium channels as the tetrodotoxin-sensitive (TTX-S) blockers such as Na v1.3 and Na v 1.7, and which are useful in the treatment or prevention of disorders and diseases in which T-type calcium channels or voltage gated sodium channels are involved. The invention also relates to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which T-type calcium channels or voltage gated sodium channels are involved. |
申请公布号 |
CA2761639(C) |
申请公布日期 |
2016.06.07 |
申请号 |
CA20102761639 |
申请日期 |
2010.05.31 |
申请人 |
RAQUALIA PHARMA INC. |
发明人 |
INOUE, TADASHI;WATANABE, SHUZO;YAMAGISHI, TATSUYA;ARANO, YOSHIMASA;MORITA, MIKIO;SHIMADA, KAORU |
分类号 |
C07D213/65;A61K31/44;A61K31/443;A61K31/4433;A61K31/4436;A61K31/4439;A61K31/444;A61K31/4706;A61K31/4709;A61K31/4725;A61K31/497;A61K31/506;A61P1/00;A61P1/18;A61P9/00;A61P9/06;A61P13/00;A61P13/10;A61P15/00;A61P19/02;A61P21/02;A61P25/00;A61P25/04;A61P25/06;A61P25/08;A61P25/14;A61P25/16;A61P25/18;A61P25/20;A61P25/22;A61P25/28;A61P29/00;A61P35/00;A61P43/00;C07D215/40;C07D241/18;C07D401/12;C07D401/14;C07D405/12;C07D409/12;C07D413/12;C07D417/12 |
主分类号 |
C07D213/65 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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