主权项 |
1. A medical article of manufacture, comprising:
(a) a lens selected from the group consisting of an intraocular lens and a contact lens that is originally free of pharmaceutically active compounds; and (b) a pharmaceutical composition incorporated into the lens, wherein the pharmaceutical composition is a suspension consisting of:
(b1) a dispersed phase consisting of solid particles consisting of a therapeutically effective quantity of a therapeutically effective quantity of at least one corticosteroid and pharmaceutically acceptable salts, hydrates, solvates, ethers, esters, acetals and ketals thereof; and(b2) a dispersion medium consisting of:
(1) a therapeutically effective quantity of at least one anti-bacterial agent independently selected from the group consisting of quinolone, a fluorinated quinolone and pharmaceutically acceptable salts, hydrates, solvates or N-oxides thereof;(2) a therapeutically effective quantity of at least one pharmaceutically acceptable solubilizing and suspending agent selected from the group consisting of non-ionic polyoxyethlene-polyoxypropylene block copolymers and polysorbates;(3) optionally, a therapeutically effective quantity of at least one glycopeptide antibiotic selected from the group consisting of vancomycin, teicoplanin, telavancin, decaplanin, ramoplanin, gentamicin, tobramycin, amikacin, cefuroxime, polymyxin B sulfate, and trimethoprim;(4) optionally, a therapeutically effective quantity of at least one non-steroid anti-inflammatory drug selected from the group consisting of bromfenac, ketorolac, etodolac, sulindac, diclofenac, aceclofenac, nepafenac, tolmetin, indomethacin, nabumetone, ketoprofen, dexketoprofen, ibuprofen, flurbiprofen, dexibuprofen, fenoprofen, loxoprofen, oxaprozin, naproxen, aspirin, salicylic acid, diflunisal, salsalate, mefenamic acid, meclofenamic acid, flufenamic acid, tolfenamic acid, meloxicam, piroxicam, ternoxicam, droxicam, lornoxicam, isoxicam, celecoxib, rofecoxib, valdecoxib, parecoxib, lumiracoxib, etoricoxib, firocoxib, nimesulide, clonixin, licofelone, and pharmaceutically acceptable salts, hydrates, solvates, ethers, esters, acetals and ketals thereof; and(5) a pharmaceutically acceptable carrier,wherein the dispersed phase is dispersed within the dispersion medium. |