发明名称 Treatment of limb ischemia
摘要 The present invention uses neural stem cells in the manufacture of a medicament for the treatment of a patient suffering peripheral arterial disease. The invention is particularly suited for treating limb ischemia or Buerger's disease.
申请公布号 US9410122(B2) 申请公布日期 2016.08.09
申请号 US201414450733 申请日期 2014.08.04
申请人 RENEURON LIMITED 发明人 Sinden John;Miljan Erik;Madeddu Paolo
分类号 A61K35/30;C12N5/0797;A61K35/12 主分类号 A61K35/30
代理机构 Saliwanchik, Lloyd & Eisenschenk 代理人 Saliwanchik, Lloyd & Eisenschenk
主权项 1. A method for treating peripheral arterial disease in a patient, comprising administering a therapeutic dose of neural stem cells to the patient; wherein, prior to administration, the neural stem cells are (i) suspended in a composition that comprises Trolox, Na+, K+, Ca2+, mg2+, Cl−, H2PO4−, HEPES, lactobionate, sucrose, mannitol, glucose, dextran-40, adenosine and glutathione and does not include a dipolar aprotic solvent, (ii) preserved at cryothermic temperatures below −20° C., and (iii) thawed; and wherein the cells are administered directly to the patient following thawing without any further processing steps.
地址 GB