| 主权项 |
1. A compound represented by Formula I: including all stereoisomers, geometric isomers, and tautomers; or a pharmaceutically acceptable salt or solvate of any of the foregoing; wherein: A1 is phenyl substituted with 1, 2, or 3 substituents independently selected from the group consisting of halogen, C1-C4 haloalkyl, and C1-C6 alkyl; R1 and R2 are independently hydrogen, halogen, C1-C4 haloalkyl, C1-C6 alkyl, C3-C6 cycloalkyl, C1-C6 alkoxy, or cyano; R3 and R4 are independently hydrogen, halogen, C1-C4 haloalkyl, C1-C6 alkyl, C3-C6 cycloalkyl, or cyano; R5 is one of the following:
(a) heterocycloalkyl, heteroaryl, phenyl, —(C1-C6 alkylene)-heterocycloalkyl, —(C1-C6 alkylene)-phenyl, —(C1-C6 alkylene)-heteroaryl, or heterocycloalkanonyl, wherein said heterocycloalkyl, heteroaryl, phenyl, and heterocycloalkanonyl are each optionally substituted with 1, 2, or 3 substituents independently selected from the group consisting of halogen, hydroxyl, C1-C6 alkyl, C1-C4 haloalkyl, C1-C6 hydroxyalkyl, C1-C6 cyanoalkyl, cyano, —CO2H, —CO2R6, —C(O)R6, —C(O)N(R7)(R8), —N(R7)C(O)(R6), —N(R7)CO2(R6), —N(R7)(R8), —O—R6, —S(O)R6, —SO2R6, —SO2N(R7)(R8), —N(R7)SO2(R6), —(C1-C6alkylene)-CO2R7, and —(C1-C6 alkylene)-C(O)N(R7)(R8);(b) C3-C6 cycloalkyl or —(C1-C6 alkylene)-(C3-C6 cycloalkyl), wherein said cycloalkyl is optionally substituted with 1, 2, or 3 substituents independently selected from the group consisting of halogen, hydroxyl, C1-C6 alkyl, C1-C1 haloalkyl, C1-C6 hydroxyalkyl, C1-C6 cyanoalkyl, cyano, —CO2H, —CO2R6, —C(O)R6, —C(O)N(R7)(R8), —N(R7)C(O)(R6), —N(R7)CO2(R6), —N(R7)(R8), —O—R6, —S(O)R6, —SO2R6, —SO2N(R7)(R8), and —N(R7)SO2(R6);(c) C1-C6 alkyl substituted by 1 or 2 substituents independently selected from the group consisting of hydroxyl, C1-C6 alkoxy, cyano, —CO2H, —CO2R6, —C(O)R6, —C(O)N(R7)(R8), —N(R7)C(O)(R6), —N(R7)(R8), —S(O)R6, —SO2R6, —SO2N(R7)(R8), and —N(R7)SO2(R6); or(d) C2-C6 alkenyl; R6 represents independently for each occurrence C1-C6 alkyl, C3-C6 cycloalkyl, aryl, or heteroaryl, each of which is optionally substituted with 1 or 2 substituents independently selected from the group consisting of hydroxyl, cyano, halogen, —CO2H, and aryl; and R7 and R8 each represent independently for each occurrence hydrogen, C1-C6 alkyl, or C3-C6cycloalkyl; or R7 and R8 are taken together with the nitrogen atom to which they are attached to form a 3 to 7 membered heterocyclic ring. |
