| 摘要 |
Methods of treating Prader-Willi syndrome in a subject in need of treatment are provided. The methods include administering to the subject an effective amount of a compound of Formula I,;;or a pharmaceutically acceptable salt thereof, wherein R, R′, X, Y and Z are defined as set forth in the specification. In embodiments, an effective amount of captodiamine or a pharmaceutically acceptable salt thereof is administered to the subject. |
| 主权项 |
1. A method of treating Prader-Willi syndrome comprising administering to a subject with Prader-Willi syndrome a pharmaceutical composition comprising an effective amount of a compound according to Formula Iwherein X is an ethylene, propylene, butylene or pentylene group; R is C1-9 alkyl, preferably C1-5 alkyl; R′ is C1-9 alkyl, alkenyl or alkynyl; Y is hydrogen, halide, hydroxyC1-4 alkyl, amino, C1-4alkylamino, acetylamino or thio; and Z is hydrogen, halide such as chloro, fluoro, iodo or bromo, hydroxyC1-4 alkyl, amino, C1-4 alkylamino, acetylamino or thio, or a pharmaceutically acceptable salt thereof. |
