Nanosomal preparation of the complex formed by quercetin (or another flavonol, flavone or a derivative thereof) and 2-hydroxypropyl-beta-cyclodextrin for intravenous use in cerebral pathological conditions

摘要

The invention involves the preparation of cholesterol lecithin nanosomes, without propylene glycol, from the complex formed by quercetin (or another flavonol or flavone or a derivative thereof) and 2-hydroxypropyl-β-cyclodextrin, by means of a process that allows the safe, effective intravenous use thereof in the treatment of cerebral pathological conditions in adults and newborns. The preparation is safe, stabilizes the altered haemodynamic parameters in severe neonatal hypoxia in newborn pigs and is effective in protecting cerebral function in experimental Parkinson's disease models and in newborn pigs subject to hypoxia.

主权项

1. An injectable formulation for intravenous administration comprising nanosomes of lecithin/cholesterol containing the complex formed by flavone and flavonol or its alkyl and sulfur derivatives with 2-hydroxypropyl-cyclodextrin, dispersed in a physiological solution, wherein the proportion lecithin cholesterol is 1:5 to 1:10; the ratio of flavone and flavonol or alkylated and/or sulfur derivatives to 2-hydroxypropyl-p-cyclodextrin is in the form of 1:20 to 1:50; and the ratio of flavone and flavonol or alkylated or sulfur derivatives to cholesterol/lecithin is from 0.5:1 to 1:10.