| 摘要 |
This invention comprises a method of transmucosal delivery of process of Vitamin B 12 without the need of intrinsic factor comprising administering a solid composition comprising a Vitamin B 12 and at least one bifunctional macromolecule with hydrophilic exterior and with hydrophobic pockets capable of pocketing Vitamin B12 material,, illustrated by cyclodextrin, at least one permeation enhancer, illustrated by Isopropyl Myristate and at least one agent that is mucoadhessive as well as penetration enhancer, illustrated by chitosan. The solid composition of Vitamin B 12 of claim 2 may comprise a lozenge, a candy, a wafer, a tablet, a patch, a film, a spray, a lip balm, or gum. |
