发明名称 Method of preparing mixed glucosamine salts
摘要 A method of preparing a therapeutically active crystalline form of glucosamine sulphate which is stable at ambient temperature and humidity and corresponds to the empirical formula: <IMAGE> (I) in which M represents a metal selected from the group consisting of Na, K, Ca, Mg, x=1 if y=2, and x=2 if y=1, wherein glucosamine hydrochloride and a sulphate of a metal selected from Na, K, Ca, Mg are reacted in the stoichiometric ratio defined by formula (I), in an aqueous solvent, and the stable crystalline form is precipitated by the addition of a liquid precipitating agent miscible with water.
申请公布号 US5847107(A) 申请公布日期 1998.12.08
申请号 US19970910749 申请日期 1997.08.13
申请人 ROTTA RESEARCH B.V. AMSTERDAM (SWISS BRANCH) 发明人 DE WAN, MAURA;VOLPI, GIUSEPPE
分类号 A61K31/70;A61K31/7008;A61P29/00;A61P43/00;C07H5/06;(IPC1-7):C07H5/06;C07H1/00 主分类号 A61K31/70
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