摘要 |
Described herein is the development of fusion proteins useful for inducing tolerance in a subject. In particular embodiments, the tolerizing agents are useful for influence autoimmune, inflammatory, and/or allergic reactions. Example tolerizing fusion proteins contain a targeting portion (which delivers the fusion protein) and a toleragen or allergen or other antigen to which tolerance is desired in a subject. In particular examples, it is demonstrated that a ps1 fusion protein, when administered orally, facilitates systemic and mucosal tolerance. Also described is the nasal delivery of fusion proteins, for instance for restoring immunogenicity.
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申请人 |
MONTANA STATE UNIVERSITY;UAB RESEARCH FOUNDATION;PASCUAL, DAVID, W.;FUJIHASHI, KOHTARO;MADDALONI, MASSIMO |
发明人 |
PASCUAL, DAVID, W.;FUJIHASHI, KOHTARO;MADDALONI, MASSIMO |