发明名称 |
PEPTIDE INHIBITORS OF CYCLIN-DEPENDENT KINASE ACTIVITY AND USES THEREOF |
摘要 |
Novel polypeptides or derivatives comprising cdk2 binding site are disclosed . The novel polypeptides or derivatives have growth suppressive activity. Nucleic acids encoding those polypeptides are also disclosed. The polypeptides identified herein are also useful in methods for treating or preventing cancer. The treatment methods comprise administration of the polypeptide to the patient. The methods also comprise contacting the sample with the above-described polypeptide or derivative, wherein the polypeptide or derivative also comprises a covalently attached detectable moiety, then determining whether the polypeptide or derivative is binding cdk2 from the sample.
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申请公布号 |
CA2603132(A1) |
申请公布日期 |
2008.04.17 |
申请号 |
CA20072603132 |
申请日期 |
2007.10.16 |
申请人 |
SBARRO HEALTH RESEARCH ORGANIZATION, INC. |
发明人 |
GIORDANO, ANTONIO |
分类号 |
C07K14/47;A61K38/17;A61P35/00;C12N9/12 |
主分类号 |
C07K14/47 |
代理机构 |
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