Methods of diagnosing or treating prostate cancer using the erg gene, alone or in combination with other over or under expressed genes in prostate cancer

摘要

The present invention relates to oncogenes or tumor suppressor genes, as well as other genes, involved in prostate cancer and their expression products, as well as derivatives and analogs thereof. Provided are therapeutic compositions and methods of detecting and treating cancer, including prostate and other related cancers. Also provided are methods of diagnosing and/or prognosing prostate cancer by determining the expression level of at least one prostate cancer-cell-specific gene, including, for example, the ERG gene or the LTF gene alone, or in combination with at least one of the AMACR gene and the DD3 gene.

主权项

1. A method of diagnosing prostate cancer in a subject, comprising:
a) measuring the expression level of a human ERG polypeptide in a biological sample from the subject, wherein the biological sample comprises prostate epithelial cells and wherein the expression level of the human ERG polypeptide is measured by an immunoassay using a monoclonal antibody that binds to the human ERG1 polypeptide and does not bind to the human ETS domain; and b) correlating the expression level of the human ERG polypeptide with the presence of prostate cancer in the subject, wherein increased expression of the human ERG polypeptide in the biological sample as compared to the expression of the human ERG polypeptide in a control sample indicates the presence of prostate cancer in the subject.