| 摘要 |
The present invention is concerned with novel quinoline derivatives having anti-Helicobacter activity of formula (I), the pharmaceutically acceptable acid addition salts therof, the stereochemically isomeric forms thereof, the quaternized forms thereof and the N-oxides thereof, wherein -A- represents a bivalent radical of formula: (a) -N=CH-CH=CH-, (b) -CH=N-CH=CH-, (c) -N = N-CH = CH-, (d) -N = CH-N = CH-, (e) -N = CH-CH = N-, (f) -CH = N-N = CH-, (g) -N = N-N = CH-, (h) -N = NCH = N-, or (i) -CH = CH-CH = CH-; R1, R2, R3, R4, R5, R6 and R7 each independently represent hydrogen, halo, hydroxy, C1-4alkyloxy, C1-4alkyl, trifluromethyl, amino, mono- or di(C1-4alkyl)- amio or nitro, provided that when one substituent on a phenyl group is a nitro then the other substituents on said phenyl group are other than nitro; novel compositions comprising said compunds, processes of preparing said compounds and compositions and methods for treating subjects suffering from disorders or afflictions associated with Helicobacter infection.
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