| 主权项 |
1. A compound of formula (I) R1 is: —CN, —S(O)mC1-6alkyl, —S(O)mC1-6cyanoalkyl, —S(O)mC1-6haloalkyl, —S(O)mC3-6cycloalkyl, —S(O)mC1-6 hydroxyalkyl, —S(O)mC1-6alkyloxy, —SO2NRaRb, —NRaS(O)mC1-6alkyl, —NRaS(O)mC3-6cycloalkyl, —S(O)(NRc)C1-6alkyl, —S(O)(NRc)C3-6cycloalkyl or —S(O)(NRc)NRaRb wherein Ra and Rb are each independently H, C1-6alkyl, C3-6cycloalkyl, C1-6haloalkyl, C1-6cyanoalkyl, or C1-6alkyloxy or; Ra and Rb taken together with the nitrogen to which they are attached form a C2-6 heterocyclic ring optionally containing 1-4 additional groups selected from NH, O and S; and m is 0, 1 or 2; and Rc is each independently H, C1-6alkyl, C3-6cycloalkyl, or C1-6alkyloxy; W is: C6-14 aryl, a C2-10 heteroaryl containing 1-4 groups selected from N, NH, O and S, saturated and partially saturated C2-10 heterocyclyl containing 1-4 groups selected from N, NH, O and S, or saturated and partially saturated C3-12 cycloalkyl ring, wherein each W is optionally substituted with 0-4 substituents selected from the group consisting of cyano, halo, hydroxy, C1-6alkyl, C1-6 haloalkyl, C1-6 hydroxyalkyl, C1-6 alkenyl, C1-6 haloalkenyl, C1-6 alkynyl, C1-6 haloalkynyl, C3-6 cycloalkyl, C3-6 heterocycle containing 1-4 groups selected from NH, O and S, C1-6 alkoxy, C3-6 cycloalkyl-oxy, —S(O)mC1-6 alkyl, —S(O)mC3-6 cycloalkyl, CN, —C(O)—NRcRd, —C(O)—ORc, —NRcRd, NRcRd—C1-6alkyl-, and RcO—C1-6alkoxy NRcRd—C1-6alkoxy-, wherein Rc and Rd is each independently H, C1-6 alkyl, C1-6 alkenyl, C1-6 alkynyl, C3-12 cycloalkyl, C6-14 aryl, C2-6 heterocycle containing 1-4 groups selected from NH, O and S, or a C2-10heteroaryl containing 1-4 groups selected from N, NH, O and S, or Rc and Rd taken together with the nitrogen to which they are attached form a C2-6 heterocyclic ring optionally containing 1-4 additional groups selected from NH, O and S; R2 is: —C1-6alkyl, —C3-6cycloalkyl, —C1-6alkyloxy, —C1-6 hydroxyalkyl, —C1-6haloalkyl, —H, —C(O)ORe, or —C(O)NReRf, wherein Re and Rf is each independently H or C1-6 alkyl; R3 is: —C1-6alkyl, —C3-6cycloalkyl, —C1-6alkyloxy; —H, —C(O)ORe, or C(O)NReRf, wherein Re and Rf is each independently H or C1-6 alkyl; or R2 and R3 taken together with the carbon to which they are attached form a C3-12 carbocyclic ring or a C2-10 heterocyclic containing 1-4 groups selected from NH, O and S; R4 is: —H, —C1-6alkyl, —C1-6alkyloxy, or —C3-6cycloalkyl; X, Y and Z are chosen independently from CRe wherein Re is: —H, -halo, —C1-6alkyl, —C1-6 haloalkyl, —C1-6 haloalkenyl, —C1-6 haloalkynyl, —C3-6 cycloalkyl, —C1-6 alkoxy, —C3-6 cycloalkyloxy, —O C1-6alkyl, —O C3-6 cycloalkyl, —S(O)mC1-6 alkyl, —S(O)mC3-6 cycloalkyl, CN, —C(O)—NRfRg, —C(O)—ORf, or —NRfRg, wherein Rf and Rg is each independently H or —C1-6 alkyl; C1-6 alkenyl, C1-6 alkynyl, C3-12 cycloalkyl, C6-14 aryl, C3-6 heterocycle containing 1-4 groups selected from N, NH, O and S, or a C2-10 heteroaryl containing 1-4 groups selected from N, NH, O and S; R5 is: —H -halo, —C1-6 alkyl, C1-6 alkenyl, —C1-6 alkoxy, —S(O)mC1-6alkyl, —C6-14 aryl, —C2-10 heterocyclyl containing 1-4 groups selected from N, NH, O and S, —C2-10 heteroaryl containing 1-4 groups selected from N, NH, O and S, —CN, —C3-C6cycloalkyl, or —C1-6haloalkyl, wherein R5 may be optionally substituted with 0-5 halo, C1-6 alkyl, C1-6 alkoxy, —S(O)mC1-6alkyl, C6-14 aryl, C2-10 heterocyclyl containing 1-4 groups selected from N, NH, O and S, or a C2-10 heteroaryl containing 1-4 groups selected from N, NH, O and S, CN, C3-C6cycloalkyl, OH or —C(O)—NRaRb, R6 is: -halo, —C1-6 alkyl —C1-6 alkenyl, —C1-6 alkoxy, —S(O)mC1-6alkyl, —C6-14 aryl, —C2-10 heterocyclyl containing 1-4 groups selected from N, NH, O and S, —C2-10 heteroaryl containing 1-4 groups selected from N, NH, O and S, —H, —CN, —C3-C6cycloalkyl, or —C1-6haloalkyl, wherein R6 may be optionally substituted with 0-5 halo, C1-6 alkyl, C1-6 alkoxy, —S(O)mC1-6alkyl, C6-14 aryl, C2-10 heterocyclyl containing 1-4 groups selected from N, NH, O and S, or a C2-10 heteroaryl containing 1-4 groups selected from N, NH, O and S, CN, C3-C6cycloalkyl, OH or —C(O)—NRaRb, or R5 and R6 taken together with the carbon to which they attached form a C3-12 carbocyclic ring or a C2-10 heterocyclic containing 1-4 groups selected from N, NH, O and S; L is: a direct bond, —C═C— —S(O)m—, —NRaS(O)m, —S(O)mNRa— —O—, —C(O)—, —(CH2)n—, —O—(CH2)n—, —N(Ra)—, —N(Ra)—(CH2)n—, —(CH2)n—N(Ra)—, —C(O)—N(Ra)—, —C(O)—N(Ra)—(CH2)n— or —N(Ra)—C(O)—N(Rb)—; wherein Ra and Rb is each independently H or C1-3 alkyl; R7 is: halo, cycloalkyl, cycloalkenyl, —C6-14 aryl, —C2-10 heterocyclyl containing 1-4 groups selected from N, NH, O and S, C2-10 heteroaryl containing 1-4 groups selected from N, NH, O and S, wherein R7 may be optionally substituted with 0-5 substituents selected from the group consisting of halogen, hydroxy, C1-6alkyl, C1-6 haloalkyl, C1-6 hydroxyalkyl, C1-6 haloalkenyl, C1-6 haloalkynyl, C3-6 cycloalkyl, C3-7 heterocycle containing 1-4 groups selected from N, NH, O and S, C6-14 aryl, C2-10 heteroaryl containing 1-4 groups selected from N, NH, O and S, C1-6 alkoxy, C1-6 haloalkoxy, C3-6 cycloalkyloxy, —S(O)mC1-6 alkyl, —S(O)mC3-6 cycloalkyl, CN, —C(O)—NRcRd, —C(O)—ORc, NRcRd and NRcRdC1-6alkyl-, wherein Rc and Rd is each independently H, C1-6 alkyl, C1-6 alkenyl, C1-6 alkynyl, cycloalkyl, —C6-14 aryl, C2-10 heterocyclyl containing 1-4 groups selected from N, NH, O and S, or a C2-10 heteroaryl containing 1-4 groups selected from N, NH, O and S, wherein each heterocyclyl, aryl or heteroaryl is optionally substituted by C1-6 alkyl, C1-6 alkoxy; or Rc and Rd—together with the nitrogen to which they are attached form a C2-6 heterocyclic ring optionally containing 1-4 additional groups selected from N, NH, O and S; each n is independently 1-4; each m is independently 0-2; or a pharmaceutically acceptable salt thereof. |
