Cancer vaccines and vaccination methods

摘要

Methods and compositions for treating cancers (e.g., neural cancers) by dendritic cell vaccination are provided herein.

主权项

1. A composition comprising dendritic cells, wherein the dendritic cells present on human leukocyte antigen (HLA) on their surface peptide epitopes, wherein the peptide epitopes are each 9 to 13 amino acids length and comprise the following six amino acid sequences:(SEQ ID NO: 3)RSDSGQQARY from AIM-2;(SEQ ID NO: 4)EADPTGHSY from MAGE-1;(SEQ ID NO: 5)SVYDFFVWL from TRP-2;(SEQ ID NO: 67)IMDQVPFSV, a superagonist peptide from gp100;(SEQ ID NO: 37)VMAGVGSPYV from HER-2;and(SEQ ID NO: 8)WLPFGFILI from IL-13 receptor α2, wherein the dendritic cells acquired the peptide epitopes in vitro by exposure to synthetic peptides comprising the peptide epitopes.