发明名称 |
NOVEL HUMAN DELTA3 COMPOSITIONS AND THERAPEUTIC AND DIAGNOSTIC USES THEREFOR |
摘要 |
The invention provides nucleic acids encoding Delta3 proteins. Also provided are derivatives of Delta3 nucleic acids, polypeptides encoded thereby, and antibodies. Delta3 therapeutics, which are either antagonists or agonists of a Delta3 bioactivity and which are capable of modulating the growth and/or differentiation of a cell, e.g., endothelial cell, are also provided herein. Furthermore, methods for treating or preventing diseases associated with an aberrant Delta3 activity and/or associated with abnormal cellular growth and/or differentiation, e.g., neurological disease or vascular disease, such as Agenesis of the Corpus Callosum with Peripheral Neuropathy (ACCPN), as well as diagnostic methods for detecting these diseases are disclosed. |
申请公布号 |
WO9845434(A1) |
申请公布日期 |
1998.10.15 |
申请号 |
WO1998US06775 |
申请日期 |
1998.04.06 |
申请人 |
MILLENNIUM BIOTHERAPEUTICS, INC. |
发明人 |
MCCARTHY, SEAN, A.;GEARING, DAVID, P. |
分类号 |
C12N15/09;A61K38/00;A61K45/00;A61P9/00;A61P21/00;A61P25/00;A61P35/00;C07K14/00;C07K14/47;C07K16/00;C07K19/00;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N9/00;C12N15/12;C12Q1/02;C12Q1/68;(IPC1-7):C12N15/12;A61K38/16;C07K16/18;C12N15/62 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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