发明名称 NOVEL COMPOUND AND ANTIVIRAL AGENT HAVING SAME AS ACTIVE INGREDIENT
摘要 [Problem] The purpose of the invention is to provide a compound that can be utilized as an antiviral agent, in particular as an anti-RNA viral agent, and especially as an anti-RS viral agent. [Solution] The invention provides a compound as indicated by formula (1) (in formula (1), R1 each independently represent a hydrogen, halogen, hydroxyl, amino, carboxyl, C1-C6 alkyl, C1-C6 alkoxyl, C1-C6 halogenoalkyl, C1-C6 alkoxycarbonyl, C1-C6 alkylamino, C2-C5 alkenyl, C3-C6 cycloalkyl, or optionally substituted aryl; R2 each independently represent a hydrogen, C1-C6 alkyl, C1-C6 halogenoalkyl, C2-C5 alkenyl, C3-C6 cycloalkyl, optionally substituted aryl, or heterocyclic group; and one or more R1 may be present in the same ring), an isomer thereof, a pharmaceutically acceptable salt of these, or a mixture of these. The compounds provided by the invention are useful as drugs for the prevention or treatment of infection by virus, especially RS virus, and in particular infection in the lower airways (e.g., bronchiolitis, pneumonia, etc.).
申请公布号 WO2016104707(A1) 申请公布日期 2016.06.30
申请号 WO2015JP86240 申请日期 2015.12.25
申请人 NATIONAL UNIVERSITY CORPORATION CHIBA UNIVERSITY 发明人 SHIRASAWA HIROSHI;ARAI TAKAYOSHI;TAMURA YUTAKA;SAITO KENGO;SUGANAMI AKIKO;OHNO YOSHIFUMI;YANAGISAWA AKIRA;MATSUMOTO SHOJI;NEMOTO TETSUHIRO;WATANABE OUJI
分类号 C07C255/41;A61K31/136;A61K31/137;A61K31/198;A61K31/277;A61K31/401;A61K31/4035;A61K31/404;A61K31/407;A61K31/4162;A61K31/4245;A61K31/4439;A61K31/555;A61K31/675;A61P31/14;A61P31/16;C07D207/16 主分类号 C07C255/41
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