| 摘要 |
Device for removing substances from blood and other fluids such as water, wastewater, chemicals and other biofluids, includes i) an electrocatalytic decomposition filter including a DC power source, a set of electrodes with a catalytic surface or in direct contact with sorbents offering catalytic activity, ii) an electrosorption filter including a DC power source, a set of electrodes, nanostructured sorption material and/or a porous polymer matrix, iii) an inlet for entry of blood or blood plasma or dialysate fluid into the device, iv) an outlet for the removal of purified blood, blood plasma, ultrafiltrate or dialysate fluid from the device, and v) a conduit connecting the inlet with the outlet and holding the electrosorption filter such that the blood, blood plasma, ultrafiltrate or dialysate fluid is forced through the electrosorption and electrocatalytic decomposition filter, and vi) a sensor and control system to safeguard the device from producing oxidative stress. |
| 主权项 |
1. A device for the removal of toxic substances from dialysate fluid, blood, blood plasma or ultra filtrate, comprising:
i) a housing having an inlet for entry of dialysate fluid, blood, blood plasma or ultrafiltrate into said housing, an outlet for the removal of purified dialysate fluid, blood, blood plasma or ultrafiltrate and excess fluid from said housing, and a conduit connecting said inlet with said outlet ii) an electrocatalytic decomposition filter for removing toxins, toxic solutes, toxic small and middle-sized molecules and protein bound toxins from the dialysate fluid, blood, bloodplasma or ultrafiltrate, said electrocatalytic decomposition filter being contained in said conduit such that said dialysate fluid, blood, blood plasma or ultrafiltrate must pass through said electrocatalytic decomposition filter when flowing from said inlet to said outlet and said electrocatalytic decomposition filter comprising: a) a set of electrodes with an electrocatalytic surface for decomposition and gasification of toxins via electro-oxidation b) or a set of electrodes that are in direct electrical contact with porous materials that have been coated with elecrocatalytic material c) power source to provide the electrodes with an electrical charge in order to activate the electrocatalytic electrode surface d) an electronic means to control and switch the electrical charge on the electrodes in view of resorbing and release of toxins and to prevent built-up of deposits on the electrodes. iii) an electrosorption filter for removing toxins, toxic solutes, toxic small and middle-sized molecules and protein bound toxins from the dialysate fluid, blood, bloodplasma or ultrafiltrate, said electrosorption filter being contained in said conduit such that said dialysate fluid, blood, blood plasma or ultrafiltrate must pass through said electrosorption filter when flowing from said inlet to said outlet and said electrosorption filter comprising: a) a nanostructured sorption material; b) a set of electrodes coated with or in electrical contact with the sorption material; c) a power source to provide the electrodes with an electrical charge and generate an electrical field strength in the sorption medium; d) a sensor unit for monitoring the quality of the cleansed fluid and a control system to correct and adjust the quality of the cleansed fluid,wherein the sensor unit is a sensor unit for monitoring the redox state the electrocatalytic decomposition rate of the cleansed fluid and the control system controls infusion of a reducing agent to correct and adjust the cleansed fluid to prevent oxidative stress wherein the electrodes are made from carbonaceous material. |
