Conjugates of GM-CSF and IL-7, and Compositions Thereof

摘要

In certain embodiments, this disclosure relates to conjugates comprising GM-CSF and IL-7 and uses related thereto, e.g., enhancing the adaptive immune system. Typically the GM-CSF and IL-7 are connected by a polymer linker, e.g., polypeptide. In certain embodiments, the disclosure relates to nucleic acids encoding these polypeptide conjugates, vectors comprising nucleic acid encoding polypeptide conjugates, and protein expression systems comprising these vectors such as infectious viral particles and host cells comprising such a nucleic acids.

主权项

1. A method of enhancing an immune response comprising administering a conjugate comprising a GM-CSF polypeptide and an IL-7 polypeptide having SEQ ID NO: 1 to a subject in need thereof.