| 发明名称 |
VACCINE COMPOSITION COMPRISING AN IMMUNOGENIC PROTEIN AND COMBINATION ADJUVANTS FOR USE IN ELICITING ANTIGEN-SPECIFIC T-CELL RESPONSES |
| 摘要 |
Vaccine compositions for use in inducing enhanced antigen-specific T cell-mediated immune responses in a subject in need thereof are disclosed. The composition comprises (a) a therapeutically effective amount of an immunogenic protein comprising at least an antigen of a pathogen; (b) a saponin-base adjuvant selected from the group consisting of GPI-0100, Quil A, QS-21; and (c) a Toll-like receptor (TLR) agonist adjuvant selected from the group consisting of monophosphoryl lipid A (MPL), and CpG1826. |
| 申请公布号 |
US2016250324(A1) |
申请公布日期 |
2016.09.01 |
| 申请号 |
US201615052713 |
申请日期 |
2016.02.24 |
| 申请人 |
TheVax Genetics Vaccine Co., Ltd. |
发明人 |
WU Chia-Mao;Wu Jiun-Ming;Chiu Yi-Tsui;Lin Yin-Ching;Chuang Hsien-Kai;Hsieh Fu-Tan;Chen Kuan-Ming |
| 分类号 |
A61K39/39;A61K38/16;A61K38/17;A61K39/12;C12N7/00 |
主分类号 |
A61K39/39 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A composition comprising:
(a) a therapeutically effective amount of an immunogenic protein comprising at least an antigen of a pathogen; (b) a saponin-base adjuvant selected from the group consisting of GPI-0100, Quil A, QS-21; and (c) a Toll-like receptor (TLR) agonist adjuvant selected from the group consisting of monophosphoryl lipid A (MPL), and CpG1826. |
| 地址 |
Taipei City TW |
