CHIRAL NUCLEIC ACID ADJUVANT HAVING ANTI-ALLERGIC ACTIVITY, AND ANTI-ALLERGIC AGENT

摘要

An adjuvant which comprises oligonucleotides which comprise two to four CpG motifs each represented by 5′-X1CpGX2-3′ and has a length of 14 to 32 nucleotides, wherein a nucleic acid at 3′ end side of at least two CpG motifs is connected by phosphorothioate linkage, wherein each nucleic acids at 3′ end and 5′ end of the oligonucleotide is S type nucleic acids connected by phosphorothioate linkage, and wherein the oligonucleotide comprises at least one nucleic acid without phosphorothioate modification. The present invention relates to an adjuvant comprising the oligonucleotide represented by the sequence number 67. The present invention relates to an anti-allergic agent comprising these adjuvant.

主权项

1. An adjuvant which comprises an oligonucleotide comprising two to four CpG motifs each represented by 5′-X1CpGX2-3′ and has a length of 14 to 32 nucleotides,
wherein the CpG is non-methylated CpG without modified phosphate backbones, wherein the X1 is A or T, wherein the X2 is A or T, wherein nucleic acids connected by phosphorothioate linkage are connected at 3′ end side of at least two CpG motifs, wherein each nucleic acids at 5′ end and 3′ end of the oligonucleotide are S type nucleic acids connected by phosphorothioate linkage, and wherein the oligonucleotide comprises at least one nucleic acid without phosphorothioate modification.