METHOD FOR ENHANCING BONE FORMATION

摘要

This invention provides a method_. for facilitating bone. formation in a subject comprising delivering to a bone formation-requiring site a composition of matter .comprising ,platelet-rich plasma, calcium, a PAR-activating agent and a bone forming material. This invention further provides a method for facilitating bone formation in a subject comprising (a) delivering to a bone formation-requiring site in the subject a composition of matter comprising platelet-rich plasma, calcium and a bone-forming material, and (b) contacting the composition so delivered with a PAR­ activating agent other than thrombin. This. invention further provides a method for facilitating clot formation in platelet-rich .plasma with a PAR-activating agent other. than thrombin. This invention further provides a method of producing a formable gel comprising the step of admixing platelet-rich plasma, calcium, a bone-forming .material and a PAR-activating agent other than thrombin. Finally, this invention provides related compositions of matter and articles of manufacture.