| 发明名称 |
ANTIANGIOGENIC DRUG FOR TREATING CANCER, ARTHRITIS AND RETINOPATHY |
| 摘要 |
<p><P>PROBLEM TO BE SOLVED: To provide peptides useful for treating pathological states which arise or are exacerbated by angiogenesis, to provide pharmaceutical compositions comprising the peptides, and to provide a method for inhibiting angiogenesis. <P>SOLUTION: Typical example is a peptide having the formula, T-Gly-Val-D-Ile-Thr-Arg-Ile-U [wherein T is absent or is selected from N-protecting group and a polypeptide of up to 12 amino acid residues optionally terminated with an N-protecting group; U is selected from Arg and Arg-NR<SP>1</SP>R<SP>2</SP>(R<SP>1</SP>and R<SP>2</SP>are each independently selected from hydrogen and 1-4C alkyl); and at least one of the amino acid residues is a D-amino acid residue]. <P>COPYRIGHT: (C)2009,JPO&INPIT</p> |
| 申请公布号 |
JP2009001576(A) |
申请公布日期 |
2009.01.08 |
| 申请号 |
JP20080164055 |
申请日期 |
2008.06.24 |
| 申请人 |
ABBOTT LAB;NORTHWESTERN UNIV |
发明人 |
HENKIN JACK;BOUCK NOEL P;DAWSON DAVID W;SCHNEIDER ANDREW J |
| 分类号 |
A61K38/00;C07K7/06;A61P1/04;A61P9/10;A61P17/06;A61P19/02;A61P27/02;A61P27/06;A61P29/00;A61P35/00;A61P35/02;A61P35/04;C07K7/08;C07K14/47;C07K14/78 |
主分类号 |
A61K38/00 |
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