FACTOR VIII: REMODELING AND GLYCOCONJUGATION OF FACTOR VIII

摘要

The invention includes methods and compositions for remodeling a peptide molecule, including the addition or deletion of one or more glycosyl groups to a peptide, and/or the addition of a modifying group to a peptide.

主权项

1. A covalent conjugate comprising Factor VIII and a linear or a branched poly(ethylene glycol), wherein the a linear or a branched poly(ethylene glycol) is conjugated directly onto the peptide backbone of Factor VIII or conjugated onto the peptide backbone of Factor VIII via a linker, wherein the in vivo half-life of the conjugate is increased by at least about 40% compared to the in vivo half-life of a wild-type Factor VIII, wherein the linear or branched poly(ethylene glycol) has a degree of polymerization of from about 1 to about 5,000.