| 发明名称 |
compostos de 7-deazapurina e purina substituída como moduladores de enzimas epigenéticas |
| 摘要 |
The present invention relates to substituted purine and 7-deazapurine compounds. The present invention also relates to pharmaceutical compositions containing these compounds and methods of treating disorders in which DOT1-mediated protein methylation plays a part, such as cancer and neurological disorders, by administering these compounds and pharmaceutical compositions to subjects in need thereof. |
| 申请公布号 |
BR112013013659(A2) |
申请公布日期 |
2016.09.06 |
| 申请号 |
BR20131113659 |
申请日期 |
2011.12.02 |
| 申请人 |
EPIZYME, INC. |
发明人 |
EDWARD JAMES OLHAVA;KEVIN WAYNE KUNTZ;RICHARD CHESWORTH;ROY MACFARLANE POLLOCK;SCOTT RICHARD DAIGLE;VICTORIA MARIE RICHON |
| 分类号 |
A61K31/52;A61K31/519;A61P3/00;A61P9/00;A61P25/28;A61P29/00;A61P35/00;A61P35/02;C07D487/04 |
主分类号 |
A61K31/52 |
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