TRANSDERMAL TESTOSTERONE DEVICE AND DELIVERY

摘要

Described are transdermal drug delivery systems for the transdermal administration of testosterone, comprising a polymer matrix and testosterone. Methods of making and using such systems also are described.

主权项

1. A transdermal drug delivery system comprising a drug-containing layer defining an active surface area and comprising a polymer matrix comprising 2-25% by weight acrylic adhesive, 45-70% by weight silicone adhesive, about 2-25% by weight soluble polyvinylpyrrolidone (PVP), about 5-15% penetration enhancer, and about 0.1-10% by weight testosterone, all based on the total dry weight of the polymer matrix, wherein the system includes less than 0.3 mg/cm2 testosterone, and achieves a testosterone flux that is at least 0.7 μg/cm2/hour, based on the active surface area.