COMPOSITIONS AND METHODS FOR TREATING HYPERKALEMIA

摘要

The present invention is directed to compositions and methods of removing potassium or treating hyperkalemia by administering pharmaceutical compositions of cation exchange polymers with low crosslinking for improved potassium excretion and for beneficial physical properties to increase patient compliance.

主权项

1. A calcium salt of a crosslinked potassium binding polymer having the structure of Formula (I):or a pharmaceutically acceptable salt thereof,
wherein: each R1 is independently selected from the group consisting of H, substituted or unsubstituted (C1-C6)alkyl, substituted or unsubstituted (C6-C18)aryl, —S(O)2OH, —OS(O)2OH, —C(O)OH, —PO(OH)2, —OP(OH)3, and —NHS(O)2OH; each R2 is independently selected from the group consisting of H, substituted or unsubstituted (C1-C6)alkyl, substituted or unsubstituted (C6-C18)aryl, —S(O)2OH, —OS(O)2OH, —C(O)OH, —PO(OH)2, —OP(OH)3, and —NHS(O)2OH; each R3 is independently selected from the group consisting of H, halogen, substituted or unsubstituted (C1-C6)alkyl, substituted or unsubstituted (C6-C18)aryl, —S(O)2OH, —OS(O)2OH, —C(O)OH, —PO(OH)2, —OP(OH)3, and —NHS(O)2OH; each X is either absent or independently selected from the group consisting of substituted or unsubstituted (C1-C6)alkyl and substituted or unsubstituted (C6-C18)aryl, each Y is independently selected from the group consisting of substituted or unsubstituted (C1-C6)alkyl and substituted or unsubstituted (C6-C18)aryl; and the mole ratio of m to n is from about 120:1 to about 40:1; and wherein the crosslinked potassium binding polymer is characterized by a crosslinking of less than 5%.