MATRIX-TYPE TRANSDERMAL PATCH FOR STEROID HORMONES

摘要

The present invention refers to a transdermal patch for the release of Estradiol and at least one progestogen agent through the skin, comprising or consisting of an outer backing foil, a matrix and a protective liner wherein a) the Estradiol and the progestogen agent(s) are present in the matrix in an oversaturated solution, b) the matrix contains 1 to 5 wt.% activated SiO2, and c) the matrix has a moisture content of less than 0.7 wt.%. The patch can be used for hormonal replacement therapy.