发明名称 |
gamma-IFN liquid-droplet aerosol and method |
摘要 |
A liquid-droplet aerosol composition for delivery to a patient's respiratory tract is disclosed. The aerosol is formed by placing an aqueous gamma-IFN solution having stabilizing and dispersing components against a plate having defined-size openings, and forcing the solution through the openings under conditions effective to form aqueous droplets having a volume mean diameter in one or more of a number of selected sizes in the 1-10 micron size range. The aerosol has the desired-size droplets and a gamma-IFN biological activity and molecular size distribution substantially the same as that of the aqueous gamma-IFN solution. Also disclosed is a method of administering to a selected region of a patient's respiratory tract, an amount of human gamma-IFN having a known, selected gamma-interferon biological activity and molecular size distribution.
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申请公布号 |
US2001043906(A1) |
申请公布日期 |
2001.11.22 |
申请号 |
US20000747383 |
申请日期 |
2000.12.22 |
申请人 |
VLASSELAER PETER VAN;EMLEN J. WOODRUFF |
发明人 |
VLASSELAER PETER VAN;EMLEN J. WOODRUFF |
分类号 |
A61K9/08;A61K9/12;A61K38/21;A61K47/10;A61K47/14;A61M15/00;A61P11/00;(IPC1-7):A61K9/00 |
主分类号 |
A61K9/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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