| 摘要 |
Hybridization between a sample nucleic acid and a probe nucleic acid with an assay having the probe nucleic acid bound on the surface of a carrier, in which a liquid is fed to the surface of the carrier and the state of the thus-fed liquid is detected. The liquid may, for example, be a hybridization liquid containing the ample nucleic acid, or it may be a washing liquid for flushing byproducts and/or reactants away from the carrier in preparation for detection of hybridization results. Because the state of the liquid is detected, accuracy of hybridization assays is improved, since it becomes possible to detect and avoid difficulties encountered during hybridization and wash processing, such as formation of bubbles and incomplete washing.
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