| 发明名称 |
Full-length infectious cDNA clones of tick borne flavivirus |
| 摘要 |
<p>Provided are full-length cDNA clones of Langat tick-borne flavivirus. In particular, the strains TP21 and E5 were obtained as full-length clones in single plasmids. Production of virions from cloned full length cDNA resulted in variants with reduced neurovirulence. Deletions in the 3' NCR also decreased neurovirulence. The affenuated variants of Langat tick-borne flavivirus may be used for vaccination purposes.</p> |
| 申请公布号 |
AU2001238156(B2) |
申请公布日期 |
2006.08.31 |
| 申请号 |
AU20010238156 |
申请日期 |
2001.02.09 |
| 申请人 |
THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES |
发明人 |
ROBERT CHANOCK;ALEXANDER PLETNEV |
| 分类号 |
C12N15/00;A61K39/12;A61K39/193;C07H21/04;C07K14/18;C12N5/00;C12N5/02;C12N7/00;C12N7/01;C12N7/04;C12N7/08;C12N15/09;C12N15/63;C12N15/70;C12N15/74 |
主分类号 |
C12N15/00 |
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