发明名称 |
PYCR1に対する天然アンチセンス転写物の阻害によるピロリン−5−カルボン酸レダクターゼ1(PYCR1)関連疾患の治療 |
摘要 |
The present invention relates to antisense oligonucleotides that modulate the expression of and/or function of Pyrroline-5-carboxylate reductase 1 (PYCR1), in particular, by targeting natural antisense polynucleotides of Pyrroline-5-carboxylate reductase 1 (PYCR1). The invention also relates to the identification of these antisense oligonucleotides and their use in treating diseases and disorders associated with the expression of PYCR1. |
申请公布号 |
JP5976548(B2) |
申请公布日期 |
2016.08.23 |
申请号 |
JP20120554080 |
申请日期 |
2011.02.21 |
申请人 |
カッパーアールエヌエー,インコーポレイテッド |
发明人 |
コラド,ジョゼフ;コルコワ シャーマン,オルガ |
分类号 |
C12N15/113;A61K31/7088;A61K31/7115;A61K31/712;A61K31/713;A61K48/00;A61P1/02;A61P1/04;A61P1/16;A61P5/00;A61P9/00;A61P9/10;A61P11/00;A61P13/02;A61P13/08;A61P13/10;A61P13/12;A61P15/00;A61P17/00;A61P17/06;A61P19/00;A61P19/02;A61P19/06;A61P19/10;A61P21/00;A61P25/00;A61P25/04;A61P25/08;A61P25/14;A61P25/16;A61P25/18;A61P25/24;A61P25/28;A61P27/02;A61P29/00;A61P35/00;A61P35/02;A61P43/00 |
主分类号 |
C12N15/113 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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