| 摘要 |
The present disclosure relates to methods for the inhibition of apolipoprotein H (apoH) and uses for the treatment of various diseases. In particular, the ability of amphipathic, nucleic-acid based polymers to bind to and inhibit the activity of apoH are disclosed herein. This inhibition is not dependent on the sequence of the nucleic acid, but rather on the presence of phosphorothioation or other sulfur modifications to increase hydrophobicity along the length of the polymer, thus rendering the oligonucleotide polymer more amphipathic.
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