发明名称 |
ARTIFICIAL MIMIC MIRNA FOR CONTROLLING GENE EXPRESSION, AND USE OF SAME |
摘要 |
The present invention provides a novel artificial mimic miRNA utilizing miRNA. An artificial mimic miRNA is a single-stranded nucleic acid including: a X region; and a Y region, the Y region and the X region being linked, wherein the X region is a guide strand sequence of a mature miRNA or a partial sequence of the guide strand sequence of the mature miRNA and consists of a linking side region (X B ) and a non-linking side region (X F ) to the Y region, the linking side region (X B ) is a sequence that does not cause intramolecular annealing within its region, and the Y region is a sequence that intramolecularly anneals to the non-linking side region (X F ) of the X region. According to the artificial mimic miRNA of the present invention, the expression of the target gene can be inhibited. |
申请公布号 |
EP3088524(A1) |
申请公布日期 |
2016.11.02 |
申请号 |
EP20140873783 |
申请日期 |
2014.12.26 |
申请人 |
TOKYO MEDICAL UNIVERSITY |
发明人 |
KURODA, MASAHIKO;OHNO, SHINICHIRO |
分类号 |
C12N15/113;A61K31/7105;A61P35/00 |
主分类号 |
C12N15/113 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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