发明名称 |
N-TERMINAL FGF VARIANTS HAVING INCREASED RECEPTOR SELECTIVITY AND USES THEREOF |
摘要 |
The present invention relates to the design, manufacture and use of fibroblast growth factor (FGF) polypeptides having improved receptor specificity. In particular, the invention relates to isolated FGF2 and FGF4 polypeptides comprising a truncated N-terminus and optionally N-terminal amino acid substitutions. The present invention provides polypeptides, nucleic acids encoding the polypeptides, compositions comprising same and methods for use thereof. |
申请公布号 |
WO2008038287(A3) |
申请公布日期 |
2009.04.23 |
申请号 |
WO2007IL01199 |
申请日期 |
2007.10.07 |
申请人 |
HEPACORE LTD.;YAYON, AVNER;ROM, ERAN;CHUMAKOV, IRINA;BLUMENSTEIN, SARA |
发明人 |
YAYON, AVNER;ROM, ERAN;CHUMAKOV, IRINA;BLUMENSTEIN, SARA |
分类号 |
A61K38/18;C07K14/50;C12N1/21;C12N5/10;C12N15/18;C12N15/63 |
主分类号 |
A61K38/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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