Applications of hyperspectral laser speckle imaging

摘要

Systems and methods are provided for detecting the flow of blood or other fluids in biological tissue by illuminating the biological tissue with two or more beams of coherent light and detecting responsively emitted light. A difference in wavelength, coherence length, beam divergence, or some other property of the beams of illumination causes the beams to preferentially scatter from, be absorbed by, or otherwise interact with respective elements of the biological tissue. Flow properties in one or more regions of the biological tissue (e.g., a region with which both beams of light preferentially interact, a region with which only one of the beams preferentially interacts) could be determined based on detected responsively emitted light from the biological tissue. Variations in speckle patterns over time and/or space, Doppler shifts, or some other properties of the detected light could be used to determine the flow properties.

主权项

1. A system comprising:
a light source, wherein the light source is configured to (i) emit a first beam of coherent illumination into a biological tissue and (ii) emit a second beam of coherent illumination into the biological tissue, wherein the first and second beams differ with respect to at least one of wavelength, coherence length, or beam divergence; a light sensor configured to receive light from the biological tissue emitted in response to illumination by the light source; and a controller operably coupled to the light sensor and light source, wherein the controller comprises a computing device programmed to perform controller operations comprising:
emitting the first beam of coherent illumination into the biological tissue using the light source;detecting, using the light sensor, a first property of light received from the biological tissue in response to illumination by the first beam of illumination;emitting the second beam of coherent illumination into the biological tissue using the light source;detecting, using the light sensor, a second property of light received from the biological tissue in response to illumination by the second beam of illumination; anddetermining at least one flow property in the biological tissue based on the first and second properties of the received light detected using the light sensor.